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Twenty-four hours later, my brain is still whirling over yesterday’s stunning news from Merck and Moderna about the success of their personalized mRNA cancer therapy in a melanoma late-stage clinical trial.

I posted this on X yesterday but it’s worth repeating here: Between this spring’s Revolution Medicines success with a KRAS-targeted drug and now Merck and Moderna’s success with an mRNA neoantigen vaccine, 2026 will go down as one of the most consequential years in cancer treatment, ever.