The US Central Command (Centcom) said it conducted "precision strikes" alongside Saudi Arabian Armed Forces against Iran-aligned groups.
It said that attacks struck several logistics and weapons sites across eastern Iraq in a "strong response to over 30 IRGC-directed aerial drone attacks in the last 72 hours".
"The IRGC and its terrorist proxies must cease these attacks to avoid further U.S. military response," Centcom added.
Earlier, a military source cited by Iranian state media denied accusations of Tehran's involvement in the firing of projectiles from other countries at targets in Saudi Arabia.